Thousands of years of suffering, with no effective treatment for Hemophilia, and then in the last few decades research has exploded.

Hemophilia Research1965 Cryoprecipitate used to treat Hemophilia.1
1968 First FIX and FVIII Concentrates.1
1982 FIX Gene cloned.1
1982 FVIII Gene cloned.1
1985 First viral inactivated factor concentrates become available.1
1992 First Recombinant product becomes available.1
1992 First Gene Therapy trials in mice.1
1993-1994 FIX First Gene Therapy in dogs.1
1993 FIX First Gene Therapy in humans 2% factor level increase.
1994 FIX Gene Therapy in dogs up to 300% increase for 1-2 months.2
1995-1996 First FIX Gene therapy in mice and dogs.1
1996 FVIII Gene Therapy in dogs well over therapeutic level for 1-2 weeks.31997 First Recombinant FIX product.1
1998 FVIII Gene Therapy in humans 4% factor level increase.1
1999 FIX Gene Therapy in humans B 1.6% increase.1
1999 FVIII Gene Therapy in mice produce 20 % increase for 11 months.4
2000 FVIII Gene Therapy in mice 4%-20% increase.5
2001 FIX Gene Therapy in humans 2%- 12% increase.1
2001 FVIII Gene Therapy in humans up to 3% increase.1
2002 FVIII Gene Therapy in mice up to 20 % increase.6
2003 FIX Gene Therapy in neonatal mice 150%-280% for more than 14 Months.72003 FIX Gene Therapy in neonatal dogs 12%- 36% increase for more than 14 Months.7
2004 FVIII Gene Therapy in mice produces 100% correction.8
2004 Vwb Factor Genetically produced in culture.9
2004 FIX Gene therapy in dogs 4%-14% increase for 3 years, observation ongoing.10
2005 Glannzman's Thrombasthenia Gene Therapy produces therapeutic levels in mice.11
2005 FVIII Gene Therapy in newborn mice and dogs produces 115% - 139% factor levels for 1 1/2 years, observation ongoing.12
2006 Gene Therapy produces FVIII stored in platelets to overcome inhibitors.14
2006 FVIIA Gene Therapy in mice produces therapeutic levels to overcome inhibitors.15
2006 FIX produced from microcapsule implanted in mice.16
2006 FIX Gene Therapy in mice produces Long Term Therapeutic levels.17
2007 FIX Gene Therapy in humans produces increases for over 3.7 years observation ongoing.18
2007 FVIII Gene Therapy in dogs and mice produces factor level increases 2%-4.5% for 27 weeks.19
2007 Vwb Factor produced by Gene Therapy.20
2007 FIX Gene Therapy in mice produces over 10% for more than 280 Days.21
2006 FVIIa Gene Therapy in mice produces FVIIa.13

1 C. Hough, D. Lillicrap (2005) Gene therapy for hemophilia: an imperative to succeed, Journal of Thrombosis and Haemostasis 3 (6), 1195-1205. doi:10.1111/j.1538-7836.2005.01401.x
2 Kay MA, Landen CN, Rothenberg SR, Taylor LA, Leland F, Wiehle S, Fang B, Bellinger D, Finegold M, Thompson AR, et al. In vivo hepatic gene therapy: complete albeit transient correction of factor IX deficiency in hemophilia B dogs.1: Proc Natl Acad Sci U S A. 1994 Mar 15;91(6):2353-7.
3 S Connelly, J Mount, A Mauser, JM Gardner, M Kaleko, A McClelland, and CD Jr Lothrop Complete short-term correction of canine hemophilia A by in vivo gene therapy Blood, Nov 1996; 88: 3846 - 3853.
4 Lang, H Study points to possible cure for hemophilia UNC-CH School of Medicine News Services June 9, 1999--No.369
5 Steven S. Fakharzadeh, Yue Zhang, Rita Sarkar, and Haig H. Kazazian, JrCorrection of the coagulation defect in hemophilia A mice through factor VIII expression in skin Blood, May 2000; 95: 2799 - 2805.
6 Arnette R. New gene therapy treatment works in mice with hemophilia A. UNC School of Medicine News Services June 10, 2002 -- No. 332
7 Lingfei Xu, Cuihua Gao, Mark S. Sands, Shi-Rong Cai, Timothy C. Nichols, Dwight A. Bellinger, Robin A. Raymer, Stephanie McCorquodale, and Katherine Parker Ponder Neonatal or hepatocyte growth factor-potentiated adult gene therapy with a retroviral vector results in therapeutic levels of canine factor IX for hemophilia B, Blood, May 2003; 101: 3924 - 3932.
8 Rita Sarkar, Renee Tetreault, Guangping Gao, Lili Wang, Peter Bell, Randy Chandler, James M. Wilson, and Haig H. Kazazian, Jr Total correction of hemophilia A mice with canine FVIII using an AAV 8 serotype Blood, Feb 2004; 103: 1253 -1260.
9 Basu, U. Banerjee, S. An engineered EBV vector expressing human factor VIII and von Willebrand factor in cultured B-cells. J Gene Med. 2004 Jul;6(7):760-8
10 Valder R. Arruda, Hansell H. Stedman, Timothy C. Nichols, Mark E. Haskins, Matthew Nicholson, Roland W. Herzog, Linda B. Couto, and Katherine A. High Regional intravascular delivery of AAV-2-F.IX to skeletal muscle achieves long-term correction of hemophilia B in a large animal model Blood, May 2005; 105: 3458 - 3464.
11 Juan Fang, Kairbaan Hodivala-Dilke, Bryon D. Johnson, Lily M. Du, Richard O. Hynes, Gilbert C. White, II, and David A. Wilcox Therapeutic expression of the platelet-specific integrin, aIIbB3 in a murine model for Glanzmann thrombasthenia Blood, Oct 2005; 106: 2671 - 2679.
12 Lingfei Xu, Timothy C. Nichols, Rita Sarkar, Stephanie McCorquodale, Dwight A. Bellinger, and Katherine P. Ponder Absence of a desmopressin response after therapeutic expression of factor VIII in hemophilia A dogs with liver-directed neonatal gene therapy PNAS 2005 102: 6080-6085; published online before print as 10.1073/pnas.0409249102
13 Paris Margaritis, Valder R. Arruda, Majed Aljamali, Rodney M. Camire, Alexander Schlachterman, and Katherine A. High Novel therapeutic approach for hemophilia using gene delivery of an engineered secreted activated Factor VII J. Clin. Invest., Apr 2004; 113: 1025 - 1031
14 Qizhen Shi, David A. Wilcox, Scot A. Fahs, Hartmut Weiler, Clive W. Wells, Brian C. Cooley, Drashti Desai, Patricia A. Morateck, Jack Gorski, and Robert R. Montgomery Factor VIII ectopically targeted to platelets is therapeutic in hemophilia A with high-titer inhibitory antibodies J. Clin. Invest., Jul 2006; 116: 1974 - 1982.
15 Margaritis P, High, KA Advances in gene therapy using factor VIIa in hemophilia. Seminars in Hematology. 2006 Jan (1Supp 1) : S101-4
16 Jianping Wen , Andrew GÅ\mez Vargas , Frederick A. Ofosu , Gonzalo Hortelano Sustained and therapeutic levels of human factor IX in hemophilia B mice implanted with microcapsules: key role of encapsulated cells, The Journal of Gene Medicine 2006 Mar;8(3):362-9
17 Bigger BW, Siapati EK, Mistry A, Waddington SN, Nivsarkar MS, Jacobs L, Perrett R, Holder MV, Ridler C, Kemball-Cook G, Ali RR, Forbes SJ, Coutelle C, Wright N, Alison M, Thrasher AJ, Bonnet D, Themis M. Permanent partial phenotypic correction and tolerance in a mouse model of hemophilia B by stem cell gene delivery of human factor IX. Gene Ther. 2006 Jan;13(2):117-26.
18 Jiang H, Pierce GF, Ozelo MC, de Paula EV, Vargas JA, Smith P, Sommer J, Luk A, Manno CS, High KA, Arruda VR. Evidence of multiyear factor IX expression by AAV-mediated gene transfer to skeletal muscle in an individual with severe hemophilia B. Mol Ther. 2006 Sep;14(3):452-5. Epub 2006 Jul 5.
19 Matsui H, Shibata M, Brown B, Labelle A, Hegadorn C, Andrews C, Hebbel RP, Galipeau J, Hough C, Lillicrap D. Ex Vivo Gene Therapy for Hemophilia A That Enhances Safe Delivery and Sustained In Vivo FVIII Expression From Lentivirally-engineered Endothelial Progenitors. Stem Cells. 2007 Jul 5; [Epub ahead of print]
20 Park SW, Choi SY. Long-Term Expression of von Willebrand Factor by a VSV-G Pseudotyped Lentivirus Enhances the Functional Activity of Secreted B-Domain-deleted Coagulation Factor VIII. Mol Cells. 2007 Aug 31;24(1):125-31
21 Brian D Brown, Alessio Cantore, Andrea Annoni, Lucia Sergi Sergi, Angelo Lombardo, Patrizia Della Valle, Armando D'Angelo, and Luigi Naldini A microRNA-regulated lentiviral vector mediates stable correction of hemophilia B mice Blood, Aug 2007; doi:10.1182/blood-2007-03-078493

WILLIAM
6/9/2016 12:49:41 am

COMPLETE CURE TO HAEMOPHILIA: My son had hemophilia for 10 years with excessive bleeding, from joints, brain. I have tried many treatment suggested by the Guru which include Inhibitor, Infusion and more other alternative prescription by our MD. Lately I was directed to a Doctor called William, who provided solution to the problem. Do not be discourage, it is a permanent treatment/cure to Haemophilia, Contact him with this email for more info: (drwilly37@ gmail. com)

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joy
12/4/2016 07:43:01 am

WOW I HAVE NEVER BELIEVE IN HERBAL REMEDIES.MY NAME IS JOY I have been a patient of tinnitus ringing ears since 35 years. I had tried a lot of anti viral med prescribed to me by doctors over the years but I could not see any improvements in my symptoms. One day while going through the internet , i got to know about this great Herbal Dr who uses his herbal remedies in curing people,quickly i contacted him and he prepared a herbal medication for me which i received and used as instructed. After few weeks the improvement were very visible. Outbreaks has stopped and the sores started to heal. I would recommend this to all my friends,families,around the globe suffering from tinnitus ringing ears.you can contact him through his email on drwilliams098765@gmail.com.THANKS TO YOU ONCE AGAIN DR WILLIAMS.

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karen
12/22/2016 02:56:39 am

How can I ever stop thanking Dr William for the great thing he have done for me, i got an accident when I was 27 years old from that day on i started experience ringing ear problem(tinnitus) i have taken all the western drugs prescribe by various doctor but to no avail . my tinnitus was very loud in the afternoon and I sleep less at night because of this problem i stop my work, few days later i was going through the Internet and I saw a post of a woman testifying about Dr William herbal remedies on how she was being cure for over her 30 years suffering from tinnitus the story Really motivated me that I have to speak with my husband about it, and he said i should give him a try, i contacted Dr William and explain all i have be facing in my life. He assured me that everything is going to be fine if only I can get his herbal portion, i said yes and I requested for it, few days later the herb was sent to me in Kuwait,i started using it as instructed by Dr William for me to take it for 21 Days which I did, can you imagine after talking Dr William herbal medicine for just two weeks i started experience results, it was like a miracle,and now i am permanently cure from this terrible tinnitus, i promise that am going to publish his herb on thing my last breath for the great deed he have done for me. For those with similar ear problem should please contact him on his email address drwilliams098765@gmail his a good man and am proud of him.

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paul
12/29/2016 11:07:38 am

CURE TO TINNITUS

Appreciation is the key to doing more that is why I have took some time out to thank some one who cured me of my 4 years tinnitus problem. It became a major problem to me as it was affecting my marital life and I was no longer comfortable so I decided to look for a solution and I came across a post of Dr williams and how he has been helping people of the same problem with his herbal remedies I contacted him and told him all I have been facing in my life. He told me how to get his product and how to take it after every thing I find out that all was now okay with me and that my tinnitus problem was gone that is why I have come out today to say thank you to him and for any tinnitus problem either from man or woman. Contact him on drwilliams098765@gmail.com his a man that take good care of his children

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Judith
2/20/2017 12:29:45 am

(MUST READ: HOW I GOT CURED FROM HEPATITIS B VIRUS)
I was diagnosed of hepatitis in 2012 and I have tried all possible means to get cure but all to no avail, until i saw a post in a health forum about a herbal clinic from South Africa who prepare herbal medicine to cure all kind of diseases including hepatitis b virus, at first i doubted if it was real but decided to give it a try, when i contact this herbal clinic via there email, they prepared a herbal medicine and sent it to me via courier service, when i received this herbal medicine, they gave me step by step instructions on how to apply it, when i applied it as instructed, i was cured of this deadly virus within 5-7 weeks of usage, I am now free from the virus, i was tasted negative. Contact this herbal clinic via there email healthherbalclinic@gmail.com or website on www.healthherbalclinic.weebly.com Goodluck

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Anthony Steven
3/8/2017 02:58:32 pm

Hello I want to share a testimony about the doctor who cured me from Fibroid after a year of looking for cure nothing works out, until this faithful day I came across a website details about cure to Fibroid, It's sound strange to me because there is nothing which I have not tried to have cure to this Fibroid but still yet I have faith in God and decided to try out once more again I contact the doctor through the email address I found there and I explained everything to him, he told me to drop my address which I did, after three days I was given the tracking number of my medicine and after three day it was delivered to me, I found a letter in it which I read carefully till I understand everything and I took the herbal medicine according to it's instructions and after a couple of one week I decided to visit the hospital to have a test, was so surprise when the doctor came in smiling and start congratulating me and give me the copy of my test result, I was so surprise to see it myself that everything have flush and wash away from my body and this is the third month now, I am not having any health issues anymore and no fibroid in me anymore. I am saying this today because I know there are many out there who need this help and for the fact God has showed me love, I have decided to show the world love too by letting them know today that there is a great doctor called Doctor Ifa who help you cure fibroid and other diseases with his herbal medicine and drugs contact him today on his email address on herbalmedicalhome@gmail.com and get free from your health problems, always remember sound health matters a lot and the Life is too short for you to loose it. Here is my email if you have any question to ask sir.anthonysteven@gmail.com and my phone number is +1 302-583-2195 and doctor email address is herbalmedicalhome@gmail.com

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richard
5/19/2017 04:57:14 pm

Hello, anyone who's reading this article of mine, my name is richard and i want you to know that there is cure for herpes2, i lived with herpes for 6years and i was unable to be my cure i have tried different doctors and non could give me the cure they help me to suppress it but that wasn't what i want, i want to free from this virus that was all i needed from them. A week ago, my friend introduce me to this man called doctor SAVE and told me how this man has cure people from genital warts, hepatitis B and c,Hiv, Cancer and advice me to contact him, i told her he cure genital warts, HIV, Hepatitis and cancer but what i need was cure for herpes, my friend persuaded me to contact him if he can also help to cure my herpes and i did. he responded back to me and after our conversation i regain hope, doctor SAVE God blessing be upon you. he sent me an herbal medicine and after i finished with his medicine i discover few days later, the cold sore around my mouth part was gone when i went to confirm it if i was really cured at same place where was i confirm that i have herpes that was the same place that i was told that their is no more herpes inside me, what a miraculous day. I want you to know that you can also contact this doctor SAVE for any cure that you need through the following means. DOCTORSAVEMANYLIFES@GMAIL.COM or rather whatsapp me through +1 267 652 8617

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chatha
9/5/2017 01:01:24 am

I have large uterine fibroid and multiple fibroid all over my womb (womb measures 15cm). I had a uterine fibroid embolisation in April last year. Before this treatment my womb measured 23cm. I still suffer every month with period pain, large blood clots and heavy bleeding. I was wondering if i would ever be okay,i try medications on hospital,the fibriod stay remain the same,my husband how has been taking care of me before abandon me,because i was unable to get pregnant for him,i was praying to God to help me out,i was chatting on facebook i sure a link,of a testimony of a man,on how Dr Ebhota help him to cure her wife fibriod,with his herbal medication,for over 6 years,after dr Ebhota treatment her wife got conceive with in two months,that was how i make up my mind to contact him,when i contact him there was no respond for two days,i was waiting for his respond,the third day he respond to me,that was how i explain every thing to him,that was how we make am agreement on how to purchase the herb,the following week of it,he send the herb to me,he gave me instruction on how i am going to be drinking the herbal potion,for 21 day,after the herb got finish,i went to met my doctor in hospital,with the doctor report shows that the fibriod has finally reduces to 3cm,immediately i call Dr Ebhota with happiness and send the cope of the result test to him,after that he also send a fertility herb to me,i am so happy,i am 3 month pregnant now,for any one out there that is passing true this problem should call him,+2349035324155 or email ,drebhota123456@gmail.com,Dr Ebhota God we always empower you and bless you to do your good work to people.

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ella
9/21/2017 12:35:25 am



Hi lovely people am so joyous today the lord has done a great thing in my life it all started last year when i came in contact with this great doctor William that changed my life , am ELLA ZOE i was diagnosed of herpes last year December that almost course me my joy and relationship i have taken treatment of different kinds gone to different places for solution but could not find any, it was really a blessing how i met doctor William that put a stop to my worries and restore my joy i was checking some comment on Facebook when i came across a comment about this great doctor helped people for cure on HIV, HERPES, COLD SORE, GENITAL WARTS and CANCER i ignore the first time i saw the comment, until i kept seen it that drew my attention to contact him through his email i saw on online we talked and he assured me of hundred percent cure, he sent me a medicine after we agreed on a term i took the medicine for some weeks as directed after i went to the hospital for confirmation and i came negative am really grateful this why am taking my time to spread this good news cause i know there are people outthere suffering from one challenges or the other this is a chance to get healthy again, Email; drwilliamherbalspel@yahoo.com or on facebook; dr.williamnaturalcure

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